Simulation of developing human neuronal cell networks
نویسندگان
چکیده
منابع مشابه
Simulation of developing human neuronal cell networks
BACKGROUND Microelectrode array (MEA) is a widely used technique to study for example the functional properties of neuronal networks derived from human embryonic stem cells (hESC-NN). With hESC-NN, we can investigate the earliest developmental stages of neuronal network formation in the human brain. METHODS In this paper, we propose an in silico model of maturating hESC-NNs based on a phenome...
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Recently evidence has accumulated that many neural networks exhibit self-organized criticality. In this state, activity is similar across temporal scales and this is beneficial with respect to information flow. If subcritical, activity can die out, if supercritical epileptiform patterns may occur. Little is known about how developing networks will reach and stabilize criticality. Here we monito...
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Self-organized criticality emerged in neural activity is one of the key concepts to describe the formation and the function of developing neuronal networks. The relationship between critical dynamics and neural development is both theoretically and experimentally appealing. However, whereas it is well-known that cortical networks exhibit a rich repertoire of activity patterns at different stage...
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ژورنال
عنوان ژورنال: BioMedical Engineering OnLine
سال: 2016
ISSN: 1475-925X
DOI: 10.1186/s12938-016-0226-6